| 产品名称 | Bax Antibody |
| 反应种属 | Human, Mouse, Rat |
| 应用 | WB, IHC |
| 推荐稀释比 | WB 1:1000-2000, IHC 1:100-200 |
| 蛋白分子量 | 21kDa |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 储存 | -20℃ |
| 背景资料 | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7 |
