产品名称 | Claudin5 Antibody |
反应种属 | Human, Mouse, Rat |
应用 | WB, IHC |
推荐稀释比 | WB 1:1000-2000, IHC 1:100-300 |
蛋白分子量 | 23KD |
宿主 | Rabbit |
克隆类型 | Polyclonal Antibody |
储存 | -20℃ |
背景资料 | Claudin-5(CLDN5) also known as BEC1, is a protein that in humans is encoded by the CLDN5 gene. By use of yeast artificial chromosomes, Claudin-5 is localized between polymorphic markers D22S944 and D22S941 on chromosome 22q11, both of which are deleted in more than 80% of VCFS patients. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. What's more, it plays a major role in tight junction-specific obliteration of the intercellular space. |