产品名称 | parkin Antibody |
反应种属 | Human, Mouse, Rat |
应用 | WB, IHC |
推荐稀释比 | WB 1:500-1000, IHC 1:200-300 |
蛋白分子量 | 52 kDa |
宿主 | Rabbit |
克隆类型 | Polyclonal Antibody |
储存 | -20℃ |
背景资料 | Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin–protein ligase activity promotes the degradation of a viariety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson’s disease. It has 8 isoforms produced by alternative splicing. |