当前位置:首页>>产品中心>>抗体

p-ERK1/2 Antibody

货号:SATSN019 规格:200μl 价格:¥ 3375.00 反应种属:Human, Mouse, Rat 应用:WB, IHC

产品介绍
产品名称p-ERK1/2 Antibody
反应种属Human, Mouse, Rat
应用WB, IHC
推荐稀释比WB 1:1000-2000, IHC 1:200-500
蛋白分子量42/44 kDa
宿主Rabbit
克隆类型Polyclonal Antibody
储存-20℃
背景资料The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at Tyrosine 204 and 187 and Threonine 177 and 160 residues mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Threonine 202 and Tyrosine 204 residues of ERK1 and Threonine 185 and Tyrosine 187 residues of ERK2 is required for full enzymatic activation. The structural consequences of dual-phosphorylation in the ERK2 include active site closure, alignment of key catalytic residues that interact with ATP, and remodeling of the activation loop. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.


标签: