| 产品名称 | E-cadherin Antibody |
| 反应种属 | Human, Mouse, Rat |
| 应用 | WB, IHC |
| 推荐稀释比 | WB 1:1000-2000, IHC 1:200-300 |
| 蛋白分子量 | 130KDa |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 储存 | -20℃ |
| 背景资料 | E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer. |
