产品名称 | caspase-9 Antibody |
反应种属 | Human, Mouse, Rat |
应用 | WB, IHC |
推荐稀释比 | WB 1:1000-2000, IHC 1:300-500 |
蛋白分子量 | 17/30/36/46kDa |
宿主 | Rabbit |
克隆类型 | Polyclonal Antibody |
储存 | -20℃ |
背景资料 | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |