| 背景资料 | Mitogen-activated protein kinase 14, also called p38-α, is an enzyme
that in humans is encoded by the MAPK14 gene. The protein encoded by
this gene is a member of the MAP kinase family. MAP kinases act as an
integration point for multiple biochemical signals, and are involved in a
wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase
is activated by various environmental stresses and proinflammatory
cytokines. The activation requires its phosphorylation by MAP kinase
kinases (MKKs), or its autophosphorylation triggered by the interaction
of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this
kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle
regulator CDC25B, and tumor suppressor p53, which suggest the roles of
this kinase in stress related transcription and cell cycle regulation,
as well as in genotoxic stress response. Four alternatively spliced
transcript variants of this gene encoding distinct isoforms have been
reported. |
